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Individual Differences in Word Recognition (McMurray et al., 2014) ...
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Individual Differences in Word Recognition (McMurray et al., 2014) ...
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Procedural and Declarative Memory Brain Systems in Developmental Language Disorder (DLD)
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In: Brain Lang (2020)
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A Real-time Mechanism Underlying Lexical Deficits in Developmental Language Disorder: Between-Word Inhibition
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In: Cognition (2019)
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Early Literacy Predictors and Second-Grade Outcomes in Children Who Are Hard of Hearing
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Alveolar and Postalveolar Voiceless Fricative and Affricate Productions of Spanish–English Bilingual Children With Cochlear Implants
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Common Genetic Variants In Foxp2 Are Not Associated With Individual Differences In Language Development ...
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An Introduction to the Outcomes of Children with Hearing Loss Study
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Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ
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Eicher, John D.; Powers, Natalie R.; Miller, Laura L.; Mueller, Kathryn L.; Mascheretti, Sara; Marino, Cecilia; Willcutt, Erik G.; DeFries, John C.; Olson, Richard K.; Smith, Shelley D.; Pennington, Bruce F.; Tomblin, J. Bruce; Ring, Susan M.; Gruen, Jeffrey R.. - : Springer Berlin Heidelberg, 2014
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Abstract:
Reading disability (RD) and language impairment (LI) are common neurodevelopmental disorders with moderately strong genetic components and lifelong implications. RD and LI are marked by unexpected difficulty acquiring and processing written and verbal language, respectively, despite adequate opportunity and instruction. RD and LI—and their associated deficits—are complex, multifactorial, and often comorbid. Genetic studies have repeatedly implicated the DYX2 locus, specifically the genes DCDC2 and KIAA0319, in RD, with recent studies suggesting they also influence LI, verbal language, and cognition. Here, we characterize the relationship of the DYX2 locus with RD, LI, and IQ. To accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association with reading, language, and IQ measures in subjects from the Avon Longitudinal Study of Parents and Children. We then replicated associations in three independent, disorder-selected cohorts. As expected, there were associations with known RD risk genes KIAA0319 and DCDC2. In addition, we implicated markers in or near other DYX2 genes, including TDP2, ACOT13, C6orf62, FAM65B, and CMAHP. However, the LD structure of the locus suggests that associations within TDP2, ACOT13, and C6orf62 are capturing a previously reported risk variant in KIAA0319. Our results further substantiate the candidacy of KIAA0319 and DCDC2 as major effector genes in DYX2, while proposing FAM65B and CMAHP as new DYX2 candidate genes. Association of DYX2 with multiple neurobehavioral traits suggests risk variants have functional consequences affecting multiple neurological processes. Future studies should dissect these functional, possibly interactive relationships of DYX2 candidate genes.
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Keyword:
Original Investigation
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URL: http://www.ncbi.nlm.nih.gov/pubmed/24509779 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053598 https://doi.org/10.1007/s00439-014-1427-3
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Longitudinal Speech Perception and Language Performance in Pediatric Cochlear Implant Users: the Effect of Age at Implantation
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Impaired statistical learning of non-adjacent dependencies in adolescents with specific language impairment
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The Influence of Hearing Aids on the Speech and Language Development of Children With Hearing Loss
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Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
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Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
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Associations of Prenatal Nicotine Exposure and the Dopamine Related Genes ANKK1 and DRD2 to Verbal Language
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Acquisition of Tense Marking in English-Speaking Children with Cochlear Implants: A Longitudinal Study
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The process of spoken word recognition in the face of signal degradation
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